Glad to see the special mention of the Mat Su Valley in Alaska. Lived there for 10 years, originally from Wisconsin. And yes, the two are VERY similar. Not the exactly the same, I did notice a difference when I moved back to WI, more nasal. But the Mat Su Valley was populated by Midwestern farmers during the Depression, so it makes sense.

Massimo Pigliucci's favorite phrase. Used to drive me insane listening to Rationally Speaking

Glad for the Disney reference. Before it became a marketing arm for Pixar movies it was an awesome venue for an optimistic future in Tomorrowland and then Epcot. It's a shadow of that former glory unfortunately.

Awesome. I think I'll put in an open records request for the cameras down the street in my little Wisconsin town. See what happens

Funny I was thinking of doing that in my little Wisconsin town too. Howdy sorta neighborish HN user.

Wonder if we should coordinate doing it simultaneously in like 10,000 cities and towns?

And my axe! Let me know if you do. (Also WI)

Too late

They know Sam has few scruples and will go for the money if the DoW says jump. These clauses mean zilch if Sam is involved

Depends on the project. For web based functionality it seems great, because of all the prior work that is out there. For more obscure things like Obsidian Note extentions or Home Assistant help it's more hit and miss

Years and years away unfortunately. Many trials and chances for failure on the human side.

It's discouraging to see these on HN and then realize that most never go anywhere, or are so far out you may not see it in your lifetime.

Maybe we should flag anything not already in a phase 3 trial :)

Well, the article notes that it seemed effective on human tissue samples.

   The researchers also tested cartilage taken from patients undergoing total knee replacement for osteoarthritis. After one week of treatment with the 15-PGDH inhibitor, the tissue showed fewer 15-PGDH-producing chondrocytes, reduced expression of cartilage degradation and fibrocartilage genes, and early signs of articular cartilage regeneration.

So, IMO that shows hope for once it goes to trials.

Useful tho

I'm always suspicious of articles like this. Having been part of a company that was the target of a few NYT articles, there is always more to the story. And parts that are just flat out wrong, but not being an expert or in the industry you just need to take their word for it and believe their anecdata.