I agree that, given this description, it's a hard problem. But can Nix find a way to abstract away these difficulties?

There are also bugs. For example, non-NixOS users of Simula are forced to run this script: https://github.com/SimulaVR/Simula/blob/master/swrast.sh

This is because a nix package expects to find a driver in `/run/opengl-driver`, which isn't always present if you're not running NixOS.