I use my laptop on my lap or in bed all the time. I own a couple of perfectly fine mice, but the reason laptops have touchpads built into them in the first place is that they're not always well suited to mice.
If I wanted a computer I could only use at a desk with a mouse, I'd have bought a desktop.
The main example I can think of is when I'm not home--sometimes it's nice to be able to use my laptop in a not-very-accommodating public space, like on the bus.
You're right, though. I try to avoid doing that whenever possible.