Just want to comment that I strongly disagree with all the commenters recommending no framework at all. If you want to make badass modern software, you need to invest in learning a framework that will help you do that. React has a learning curve and there are gotchas if you don't take the time to internalize a solid mental model of how it works (reading docs, watching lots of youtube videos over lunch, shooting yourself in the foot many times, etc) - but in the end it is insane the number of problems it solves for you compared to just writing stuff from scratch. I was a FE dev in 2009, I remember the before-times, and I remember backbone, Dojo, etc that were all hot garbage. The expressive power of React (and other modern frameworks) and velocity that is possible is insane compared to writing everything with just js.

* Also note, this isn't just about react vs Vue (for example). You'll have to make like 20 tooling choices here.