A lot of people are annoyed that many one-handed shortcuts become two-handed on Dvorak. I switched before I knew about OS X's Dvorak-Qwerty ⌘ mode, but I almost went back to Qwerty because of the shortcuts.
That's interesting. I actually appreciate that certain shortcuts become two-handed. The proximity (on QWERTY) of X, C, and V to the left ⌘ key promotes a cramped, claw-like chording that is antithetical to the purpose of Dvorak (ergonomics). I find myself wishing that the X key were on the right hand for this reason.
Of course---neither layout dictates a 1 or 2 hand maneuver because there are two ⌘ keys, but I think it's common for users to want to use one or the other (for me, the left, unless I'm using it with the + and - keys, for some reason).
