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> I'm still confused why all the attempts at clearing amyloid plaque don't stop progression of the disease

Newer drugs aimed at inhibiting amyloid-beta plaque formation in early-stage Alzheimer’s disease are showing an effect. There’s a long ways to go, but it doesn’t look like the amyloid-beta theory is dead. There is likely something there.

https://en.wikipedia.org/wiki/Lecanemab



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