TypedDicts "aren't real" in the sense that they're a compile-time feature, so you're getting typing without any deserialization cost beyond the original JSON. Dataclasses and Pydantic models are slow to construct, so that's not nothing.
Pydantic v1 was slow enough for them to write a lot of the core logic in Rust for Pydantic v2, and for the previous sloth to have been an argument people launched against it if you look back at threads on here and Reddit comparing it to other libraries.
Pydantic's JSON parsing is faster than the built-in module, on par with orjson, but creating model instances and run-time type checking net out to be much slower. I linked msgspec's benchmarks in the previous post.
This of course means TypeDicts don't give you run-time validation. For that, and for full-blown custom types in general, I tend to favor msgspec Structs: https://jcristharif.com/msgspec/benchmarks.html#json-seriali....