Sure, but don't forget to look for posted signs, like:

"In Upper Manhattan, downtown 1 skips 137 St-City College, 125 St, 116 St-Columbia University, Cathedral Pkwy (110 St) and 103 St

    Aug 1 - 4, Fri 9:45 PM to Mon 5:00 AM 

For service to these stations, take the 1 to 96 St and transfer to an uptown 1.

For service from these stations, take the 1 to 168 St and transfer to a downtown 1." [1]

There are often many simultaneous service changes.

[1] https://www.mta.info/