Absolutely. I'm using it on RP2040, and it's actually superfun to have real low-level code working in parallel.
In my case, one CPU is doing the CAN-based communication and the device control loop, and the other core is providing the IP-based interface with SNMP-based monitoring.
In my case, one CPU is doing the CAN-based communication and the device control loop, and the other core is providing the IP-based interface with SNMP-based monitoring.