That doesn't really strike me as relevant? Many "businesses" are one or two people. Obviously "giant" is subjective but considering the largest companies are a few orders of magnitude bigger, I maintain what I said earlier: Only people who are immersed in the startup world consider Dropbox a "giant" company.
Just to add some objectivity to the debate, in France, between 250 and 4999 employees a company is considered to be an "intermediate size company" (as long as the revenue is below 1.5 G€).
I don't know the American standard, but I'd be surprised if it isn't similar.