If you look at the continued sanctions against Russia, it's definitely possible. Never underestimate political demonstrations of power regardless of money involved, just remember the Berlin Air Lift...

That's the whole point. Politicians send messages of their power rather than of their economy.

Well, the people have sent their message.

The North of England has seen their manufacturing base migrate to the cheaper countries of the EU while the SE reaps the rewards of the service economy.

The seeds have bloomed, enjoy the fruits.

Agree, I didn't consider this.

yes, we already have the far right in france and the netherlands calling for their own referendum, the EU can't risk losing these countries and others as well, so they are willing to go to great lengths to not give these countries more reasons to leave

An EU exit of more states would cost more.

But is inevitable. It's not even 9am the morning of the vote and there are already calls for referendums all over Europe.